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Gene CTNNB1
Variant S33Y
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions CTNNB1 S33Y lies within the ubiquitination recognition motif of the Ctnnb1 protein and occurs at a Gsk3b phosphorylation site on the Ctnnb1 protein (PMID: 15064718). S33Y confers a gain of function to the Ctnnb1 protein as demonstrated by nuclear accumulation of Ctnnb1, increased Ctnnb1-driven transcription, and increased proliferation of cells in culture (PMID: 18757411).
Associated Drug Resistance
Category Variants Paths

CTNNB1 mutant CTNNB1 act mut CTNNB1 S33Y

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Transcript NM_001098210.2
gDNA chr3:g.41224610C>A
cDNA c.98C>A
Protein p.S33Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005264886 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_047447479.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_017005738.2 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001098210.2 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_047447480.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001098209.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_017005738.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001904.3 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001904.4 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001098209 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_024453358.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001098209.2 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_006712985.2 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_024453356.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001098210 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_024453356.2 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_047447481.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001904 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_024453357.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
NM_001098210.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_006712985.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_047447483.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_047447477.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38
XM_047447478.1 chr3:g.41224610C>A c.98C>A p.S33Y RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CTNNB1 S33Y colorectal adenocarcinoma predicted - sensitive NMS-P715 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 S33Y colorectal adenocarcinoma predicted - sensitive Mps1-IN-1 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y demonstrated increased sensitivity to Mps1-IN-1 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 S33Y colorectal adenocarcinoma predicted - sensitive BAY1161909 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 S33Y colorectal adenocarcinoma predicted - sensitive BAY1217389 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to BAY1217389 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 S33Y colorectal adenocarcinoma predicted - sensitive Mps-BAY2b Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to Mps-BAY2b compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 S33Y colorectal adenocarcinoma predicted - sensitive MPI-0479605 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y demonstrated increased sensitivity to MPI-0479605 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540
CTNNB1 S33Y colorectal adenocarcinoma predicted - sensitive NTRC 0066-0 Preclinical - Cell culture Actionable In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal carcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to NTRC 0066-0 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540). 28751540