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Therapy Name	BAY1161909
Synonyms
Therapy Description	BAY1161909 (Empesertib), an inhibitor of TTK (MPS1), inhibits the spindle assembly checkpoint to induce cell death (PMID: 28539250, PMID: 32338514).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
BAY1161909		BAY 1161909\|Empesertib	MPS1 Inhibitor 27	BAY1161909 (Empesertib), an inhibitor of TTK (MPS1), inhibits the spindle assembly checkpoint to induce cell death (PMID: 28539250, PMID: 32338514).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	BAY1161909	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	BAY1161909	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colorectal adenocarcinoma	predicted - sensitive	BAY1161909	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 T41A	lung cancer	predicted - sensitive	BAY1161909	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to BAY1161909 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540

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