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Therapy Name	NMS-P715
Synonyms
Therapy Description	NMS-P715 is a selective inhibitor of TTK (MPS1) that inhibits spindle assembly checkpoint thereby preventing cell proliferation (PMID: 21159646, PMID: 28726638).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
NMS-P715		NMS P715	MPS1 Inhibitor 27	NMS-P715 is a selective inhibitor of TTK (MPS1) that inhibits spindle assembly checkpoint thereby preventing cell proliferation (PMID: 21159646, PMID: 28726638).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
CTNNB1 S33Y	colorectal adenocarcinoma	predicted - sensitive	NMS-P715	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S33Y, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45del	colon carcinoma	predicted - sensitive	NMS-P715	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colon carcinoma cell line harboring CTNNB1 S45del, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 S45F	colorectal adenocarcinoma	predicted - sensitive	NMS-P715	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a colorectal adenocarcinoma cell line harboring CTNNB1 S45F, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540
CTNNB1 T41A	lung cancer	predicted - sensitive	NMS-P715	Preclinical - Cell culture	Actionable	In a preclinical study, cell lines harboring CTNNB1 hotspot mutations, including a lung cancer cell line harboring CTNNB1 T41A, demonstrated increased sensitivity to NMS-P715 compared to cell lines with wild-type CTNNB1 in culture (PMID: 28751540).	28751540

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