NTRK2 R458G
Gene Variant Detail

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Gene NTRK2
Variant R458G
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions NTRK2 R458G lies within the cytoplasmic domain of the Ntrk2 protein (UniProt.org). R458G results in cell surface expression and receptor dimerization similar to wild-type Ntrk2 but leads to increased phosphorylation of Ntrk2, Akt, and Erk, and IL3-independent growth in culture (PMID: 32315394).
Associated Drug Resistance
Category Variants Paths

NTRK2 mutant NTRK2 act mut NTRK2 R458G

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Transcript NM_001018064.3
gDNA chr9:g.84752061A>G
cDNA c.1372A>G
Protein p.R458G
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.