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Gene TET2
Variant N870S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TET2 N870S does not lie within any known functional domains of the Tet2 protein (UniProt.org). N870S has not been characterized in the scientific literature and therefore, its effect on Tet2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 N870S

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Transcript NM_001127208.3
gDNA chr4:g.105236551A>G
cDNA c.2609A>G
Protein p.N870S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005263082.3 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_047415843.1 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
NM_017628.4 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_047415841.1 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_006714242.3 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
NM_017628.4 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_047415842.1 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_017008319.2 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_006714242.4 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_047415840.1 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_017008319.1 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38
XM_047415839.1 chr4:g.105236551A>G c.2609A>G p.N870S RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TET2 mutant myelofibrosis not applicable N/A Guideline Diagnostic TET2 mutations aid in the diagnosis of primary myelofibrosis in the absence of JAK2, CALR, or MPL mutations (NCCN.org). detail...
TET2 mutant angioimmunoblastic T-cell lymphoma not applicable N/A Guideline Diagnostic TET2 mutations aid in the diagnosis of angioimmunoblastic T-cell lymphoma (NCCN.org). detail...
TET2 mutant acute myeloid leukemia sensitive Olaparib Preclinical - Patient cell culture Actionable In a preclinical study, Lynparza (olaparib) treatment inhibited colony formation in patient-derived acute myeloid leukemia cells harboring a TET2 mutation along with FLT3-ITD and NPM1 mutation in culture (PMID: 34215619). 34215619
TET2 mutant acute myeloid leukemia not applicable N/A Clinical Study Prognostic In multiple clinical studies, including a meta-analysis, TET2 mutations were associated with shorter overall survival in patients with acute myeloid leukemia (PMID: 24524305, PMID: 25412851, PMID: 24994606). 24524305 25412851 24994606
TET2 mutant acute myeloid leukemia predicted - sensitive Azacitidine Phase I Actionable In a retrospective analysis, presence of a TET2 mutation correlated with higher overall response rate (ORR) in patients with myelodysplastic syndrome and acute myeloid leukemia following treatment with Vidaza (azacitidine), with an ORR of 85% (11/3) in TET2-mutated patients, compared to 47% (34/47) in patients with wild-type TET2, but did not correlate with overall survival (PMID: 21494260). 21494260