ALK D1225N
Gene Variant Detail

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Gene ALK
Variant D1225N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ALK D1225N lies within the protein kinase domain of the Alk protein (UniProt.org). D1225N has been identified in the scientific literature (PMID: 37529699), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Sep 2025).
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK D1225N

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Transcript NM_004304.5
gDNA chr2:g.29214054C>T
cDNA c.3673G>A
Protein p.D1225N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29214054C>T c.3673G>A p.D1225N RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29214054C>T c.3673G>A p.D1225N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ALK D1225N lung adenocarcinoma predicted - sensitive Crizotinib Case Reports/Case Series Actionable In a clinical case study, Xalkori (crizotinib) treatment resulted in a partial response in a patient with metastatic lung adenocarcinoma harboring ALK D1225N (PMID: 37529699). 37529699
ALK D1225N lung adenocarcinoma predicted - sensitive Ensartinib Case Reports/Case Series Actionable In a clinical case study, Ensacove (ensartinib) treatment resulted in a partial response in a patient with metastatic lung adenocarcinoma harboring ALK D1225N (PMID: 37529699). 37529699