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| Profile Name | ERBB3 over exp |
| Gene Variant Detail | |
| Relevant Treatment Approaches | HER inhibitor (Pan) HER2 (ERBB2) Antibody HER2 (ERBB2) Vaccine HER2 Inhibitor HER3 (ERBB3) Antibody HER3 Inhibitor |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ERBB3 over exp | prostate cancer | sensitive | HER3 (ERBB3) Antibody | Patritumab deruxtecan | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Patritumab deruxtecan (U3-1402) inhibited growth of patient-derived prostate cancer cells with high ERBB3 (HER3) expression in culture and in a patient-derived xenograft (PDX) model, but did not demonstrate anti-tumor activity in cell lines with low ERBB3 (HER3) expression (PMID: 34753775). | 34753775 |
| ERBB3 over exp | prostate cancer | predicted - sensitive | HER3 (ERBB3) Antibody | Patritumab | Preclinical - Pdx & cell culture | Actionable | In a preclinical study, Patritumab (U3-1287) treatment decreased viability of patient-derived prostate cancer cells with high ERBB3 (HER3) expression in culture but did not inhibit tumor growth in a patient-derived xenograft (PDX) model, and did not demonstrate anti-tumor activity in cell lines with low ERBB3 (HER3) expression (PMID: 34753775). | 34753775 |
| ERBB3 over exp | breast cancer | sensitive | HER3 (ERBB3) Antibody | Patritumab deruxtecan | Preclinical - Cell culture | Actionable | In a preclinical study, Patritumab deruxtecan (U3-1402) treatment inhibited growth of a breast cancer cell line overexpressing Erbb3 (Her3) in culture (PMID: 35503762). | 35503762 |
| ERBB3 over exp | triple-receptor negative breast cancer | predicted - sensitive | HER3 (ERBB3) Antibody | Patritumab deruxtecan | Phase Ib/II | Actionable | In a Phase I/II trial (U31402-A-J101), Patritumab deruxtecan (U3-1402) therapy demonstrated safety and efficacy in previously treated metastatic triple-negative breast cancer patients with high ERBB3 (HER3) (>/=75% membrane positivity) levels (n=53), with an objective response rate of 22.6%, disease control rate of 79.2%, with partial response in 22.6% and stable disease in 56.6% of patients, median progression-free survival of 5.5 mo, and median overall survival of 14.6 mo (PMID: 37801674; NCT02980341). | 37801674 |
| ERBB3 over exp | Her2-receptor positive breast cancer | predicted - sensitive | HER3 (ERBB3) Antibody | Patritumab deruxtecan | Phase Ib/II | Actionable | In a Phase I/II trial (U31402-A-J101), Patritumab deruxtecan (U3-1402) therapy demonstrated safety and efficacy in previously treated metastatic ERBB2 (HER2)-positive breast cancer patients with high ERBB3 (HER3) (>/=75% membrane positivity) levels (n=14), with an objective response rate of 42.9%, disease control rate of 92.9%, with partial response in 42.9% and stable disease in 50% of patients, median progression-free survival of 11 mo, and median overall survival of 19.5 mo (PMID: 37801674; NCT02980341). | 37801674 |