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| Profile Name | TP53 Y327L |
| Gene Variant Detail | |
| Relevant Treatment Approaches | p53 Activator p53 Gene Therapy |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| TP53 Y327L | ovarian carcinoma | sensitive | p53 Activator | ReACp53 | Preclinical | Actionable | In a preclinical study, ReACp53 induced cell death in human primary ovarian carcinoma cells harboring TP53 Y327L in culture (PMID: 26748848). | 26748848 |