Molecular Profile Detail

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT03209401	Phase I	Carboplatin + Niraparib	Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies	Terminated	USA	0
NCT05379972	Phase II	Olaparib + Pembrolizumab	Study of SBRT/Olaparib Followed by Pembrolizumab/Olaparib in Gastric Cancers	Recruiting	USA	0
NCT03317119	Phase I	Trametinib + Trifluridine-tipiracil hydrochloride	Trametinib and Trifluridine and Tipiracil Hydrochloride in Treating Patients With Colon or Rectal Cancer That is Advanced, Metastatic, or Cannot Be Removed by Surgery	Completed	USA	0
NCT02189174	Phase Ib/II	CLR457	Study of CLR457 Administered Orally in Adult Patients With Advanced Solid Malignancies	Terminated	USA \| ESP \| CAN	2
NCT04632992	Phase II	Ipatasertib Atezolizumab + Capecitabine Entrectinib Atezolizumab + Docetaxel Ado-trastuzumab emtansine + Atezolizumab Capecitabine + Pertuzumab/trastuzumab/hyaluronidase-zzxf Paclitaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Alectinib Inavolisib Pertuzumab/trastuzumab/hyaluronidase-zzxf Docetaxel + Pertuzumab/trastuzumab/hyaluronidase-zzxf Atezolizumab + Paclitaxel Ado-trastuzumab emtansine + Tucatinib	A Study Evaluating Targeted Therapies in Participants Who Have Advanced Solid Tumors With Genomic Alterations or Protein Expression Patterns Predictive of Response (MyTACTIC)	Completed	USA	0
NCT02761694	Phase I	ARQ 751 + Paclitaxel ARQ 751 ARQ 751 + Fulvestrant	ARQ 751 as a Single Agent or in Combination With Other Anti-Cancer Agents, in Solid Tumors With PIK3CA / AKT / PTEN Mutations	Terminated	USA	0
NCT05843253	Phase II	Everolimus + Ribociclib	Study of Ribociclib and Everolimus in HGG and DIPG	Recruiting	USA \| NLD \| GBR \| DEU \| CAN \| AUS	0
NCT01884285	Phase I	AZD8186 Abiraterone + AZD8186 AZD8186 + Vistusertib	AZD8186 First Time In Patient Ascending Dose Study	Completed	USA \| GBR \| ESP \| CAN	0
NCT03218826	Phase I	AZD8186 + Docetaxel	PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery	Active, not recruiting	USA	0
NCT06764186	Phase III	Capivasertib + Fulvestrant	A Phase IIIB Study to Evaluate the Use of Capivasertib in Combination With Fulvestrant in Patients With Advanced Breast Cancer Who Have Relapsed/Progressed on ET and CDK4/6 Inhibitor Reflecting Real World Clinical Practice in Spain (CAPItana)	Recruiting	ESP	0
NCT04770246	Phase II	TAS-117	TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations	Terminated	USA \| GBR \| FRA \| AUT	0
NCT03842228	Phase I	Copanlisib + Durvalumab + Olaparib	Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations	Active, not recruiting	USA	0
NCT05082025	Phase II	Copanlisib + Fulvestrant	Phase 2 Study of PI3K Inhibitor Copanlisib in Combination With Fulvestrant in Selected ER+ and/or PR+ Cancers With PI3K (PIK3CA, PIK3R1) and/or PTEN Alterations	Active, not recruiting	USA	0
NCT02401347	Phase II	Talazoparib	Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumors	Completed	USA	0
NCT04317105	Phase Ib/II	Copanlisib + Ipilimumab + Nivolumab Copanlisib + Nivolumab	Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN	Active, not recruiting	USA \| CAN	0
NCT05038839	Phase I	Cabozantinib + Pamiparib	Cabozantinib and Pamiparib for the Treatment of Advanced of Refractory Solid Tumors	Active, not recruiting	USA	0
NCT04108858	Phase Ib/II	Copanlisib + Pertuzumab + Trastuzumab Pertuzumab + Trastuzumab	Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Maintenance Treatment (Trastuzumab and Pertuzumab) After Initial Chemotherapy in a Phase Ib/II Trial for Advanced HER2 Positive Breast Cancer	Terminated	USA	0
NCT02920450	Phase Ib/II	Carboplatin + Gedatolisib + Paclitaxel	Study of Paclitaxel, Carboplatin, and PF-05212384 in Advanced or Metastatic NSCLC (UF-STO-LUNG-002)	Terminated	USA	0
NCT05010096	Phase I	Copanlisib + Elimusertib	BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors	Withdrawn		0
NCT06085729	Phase Ib/II	ADI-PEG 20 + Cabazitaxel + Carboplatin	Phase I/II Study of PEGylated Arginine Deiminase (ADI-PEG20) With Carboplatin and Cabazitaxel in Men With Aggressive Variant Prostate Cancers (AVPC)	Active, not recruiting	USA	0
NCT05455619	Phase Ib/II	Capivasertib + Fulvestrant + SDX-7320 Alpelisib + Fulvestrant + SDX-7320	Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Women With a PI3K Alteration and HR+/Her2- Breast Cancer (Amelia-1)	Recruiting	USA	0
NCT05554380	Phase II	Ipatasertib + Paclitaxel	Study of Chemotherapy Plus Ipatasertib for People With Solid Tumors With AKT Mutations, A ComboMATCH Treatment Trial	Recruiting	USA	1
NCT04216472	Phase II	Alpelisib + Nab-paclitaxel	Nab-paclitaxel and Alpelisib for the Treatment of Anthracycline Refractory Triple Negative Breast Cancer With PIK3CA or PTEN Alterations	Active, not recruiting	USA	0
NCT01097278	Phase 0	Cholecalciferol	S0812 High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer	Completed	USA	0
NCT06239467	Phase I	OKI-219 + Trastuzumab OKI-219 Fulvestrant + OKI-219	First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer (PIKture-01)	Recruiting	USA \| ITA \| FRA \| ESP \| BEL	1

Profile Name	PTEN inact mut
Gene Variant Detail	PTEN inact mut (loss of function)
Relevant Treatment Approaches	Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor PI3K Inhibitor (Pan) PIK3CB inhibitor

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