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Profile Name | JAK2 amp |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
JAK2 amp | triple-receptor negative breast cancer | sensitive | NVP-BSK805 + Paclitaxel | Preclinical - Pdx | Actionable | In a preclinical study, NVP-BSK805 with Abraxane (paclitaxel) inhibited tumor growth in triple-negative breast cancer patient-derived xenograft models with JAK2 amplification (PMID: 27075627). | 27075627 | |
JAK2 amp | triple-receptor negative breast cancer | sensitive | NVP-BSK805 | Preclinical - Pdx | Actionable | In a preclinical study, NVP-BSK805 inhibited tumor growth in triple-negative breast cancer patient-derived xenograft models harboring JAK2 amplification (PMID: 27075627). | 27075627 |