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| Profile Name | MERTK over exp |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| MERTK over exp | Advanced Solid Tumor | sensitive | RXDX-106 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, RXDX-106 inhibited Tam-family kinases activity in transformed cells overexpressing Mertk in culture and resulted in tumor growth inhibition in cell line xenograft models (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31). | detail... | |
| MERTK over exp | gastric adenocarcinoma | sensitive | RXDX-106 | Preclinical - Patient cell culture | Actionable | In a preclinical study, RXDX-106 inhibited proliferation of patient derived gastric cancer cells overexpressing Mertk (PMID: 29285287). | 29285287 |