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Ref Type

PMID

Authors

E. Lew, C. Walsh, E. Martin, A. Albert, G.G. Li, Y. Yokoyama

Title

Immuno-oncologic efficacy of RXDX-106, a selective, TAM family small molecule kinase inhibitor

Journal	Vol	Issue	Date	Pages	Journal Short Title
European Journal of Cancer	69		December 2016

URL

http://www.sciencedirect.com/science/article/pii/S0959804916326739?via%3Dihub

Abstract Text

European Journal of Cancer, Vol 69, Supplement 1, December 2016, Page S31

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Therapy Name	Drugs	Efficacy Evidence	Clinical Trials
RXDX-106	RXDX-106	4	0

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
RXDX-106		CEP-40783\|CEP40783\|CEP 40783\|RXDX106\|RXDX 106	AXL Inhibitor 30 MERTK Inhibitor 13 MET Inhibitor 59 TYRO3 Inhibitor 7	RXDX-106 (CEP-40783) is a small molecule inhibitor of TAM family kinases (Axl, Mertk, and Tyro3) and Met that promotes anti-tumor immune response, resulting in tumor growth inhibition (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31, PMID: 30501104, PMID: 30723115).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
AXL over exp	Advanced Solid Tumor	sensitive	RXDX-106	Preclinical - Cell line xenograft	Actionable	In a preclinical study, RXDX-106 inhibited Tam-family kinases activity in transformed cells over expressing Axl in culture, resulted in tumor growth inhibition in cell line xenograft models (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31).	detail...
MERTK over exp	Advanced Solid Tumor	sensitive	RXDX-106	Preclinical - Cell line xenograft	Actionable	In a preclinical study, RXDX-106 inhibited Tam-family kinases activity in transformed cells overexpressing Mertk in culture and resulted in tumor growth inhibition in cell line xenograft models (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31).	detail...
TYRO3 over exp	Advanced Solid Tumor	sensitive	RXDX-106	Preclinical - Cell line xenograft	Actionable	In a preclinical study, RXDX-106 inhibited Tam-family kinases activity in transformed cells overexpressing Tyro3 in culture, resulting in tumor growth inhibition in cell line xenograft models (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31).	detail...

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