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Profile Name | MSH3 loss |
Gene Variant Detail | |
Relevant Treatment Approaches |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
MSH3 loss | colon cancer | sensitive | KU60648 + Radiotherapy | Preclinical - Cell culture | Actionable | In a preclinical study, KU60648 combined with irradiation resulted in enhanced sensitivity compared to KU60648 alone in MSH3 deficient colon cancer cells in culture, demonstrating reduced colony formation (PMID: 28224663). | 28224663 | |
MSH3 loss | colorectal cancer | predicted - sensitive | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, MSH3-deficient colorectal cancer cells demonstrated increased sensitivity to growth inhibition by Lynparza (olaparib) compared to cells expressing MSH3 in culture (PMID: 21285347). | 21285347 |