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| Profile Name | CDK12 del |
| Gene Variant Detail | |
| Relevant Treatment Approaches | Olaparib |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| CDK12 del | prostate cancer | sensitive | Olaparib | Olaparib | Preclinical - Cell culture | Actionable | In a preclinical study, Lynparza (olaparib) treatment inhibited viability of prostate cancer cell lines with biallelic CDK12 truncations in culture (PMID: 39321214). | 39321214 |
| CDK12 del | prostate cancer | sensitive | Talazoparib | Preclinical - Cell culture | Actionable | In a preclinical study, Talzenna (talazoparib) treatment inhibited viability of prostate cancer cell lines with biallelic CDK12 truncations in culture (PMID: 39321214). | 39321214 | |
| CDK12 del | prostate cancer | sensitive | Veliparib | Preclinical - Cell culture | Actionable | In a preclinical study, Lynparza (olaparib) treatment inhibited viability of a prostate cancer cell line with biallelic CDK12 truncations in culture (PMID: 39321214). | 39321214 | |
| CDK12 del | prostate cancer | sensitive | Rucaparib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Rubraca (rucaparib) treatment inhibited viability of prostate cancer cell lines with biallelic CDK12 truncations in culture and inhibited tumor growth in a cell line xenograft model (PMID: 39321214). | 39321214 |