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Profile Name POLE inact mut
Gene Variant Detail

POLE inact mut (loss of function)

Relevant Treatment Approaches

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06712472 Phase III Olaparib Randomized Phase III Trial Testing Maintenance Olaparib Versus Observation After Adjuvant Chemoradiation for P53abn Endometrial Cancer (RAINBO-RED) Recruiting FRA 0
NCT02715284 Phase I Dostarlimab-gxly Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors (GARNET) Active, not recruiting USA | POL | ITA | GBR | FRA | ESP | DNK | CZE | CAN | BRA 0
NCT06084416 Phase I AMG 650 A Study of Sovilnesib in Subjects With Ovarian Cancer Active, not recruiting USA 0
NCT04500548 Phase I Nivolumab Ipilimumab + Nivolumab Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study Withdrawn USA | CAN 0
NCT07227636 Phase II Balstilimab + Botensilimab A Study of Botensilimab and Balstilimab for Colorectal Cancer Recruiting USA 0