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| Profile Name | POLE inact mut |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07227636 | Phase II | Balstilimab + Botensilimab | A Study of Botensilimab and Balstilimab for Colorectal Cancer | Recruiting | USA | 0 |
| NCT06712472 | Phase III | Olaparib | Randomized Phase III Trial Testing Maintenance Olaparib Versus Observation After Adjuvant Chemoradiation for P53abn Endometrial Cancer (RAINBO-RED) | Recruiting | FRA | 0 |
| NCT06084416 | Phase I | AMG 650 | A Study of Sovilnesib in Subjects With Ovarian Cancer | Active, not recruiting | USA | 0 |
| NCT04500548 | Phase I | Nivolumab Ipilimumab + Nivolumab | Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study | Withdrawn | USA | CAN | 0 |