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| Profile Name | ERBB3 E928A |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| ERBB3 E928A | triple-receptor negative breast cancer | predicted - sensitive | Capecitabine + Trastuzumab | Case Reports/Case Series | Actionable | In a clinical case study, treatment with the combination of Herceptin (trastuzumab) and Xeloda (capecitabine) resulted in a partial response and reduction in circulating tumor markers, with clinical benefit ongoing after 10 months, in a triple-receptor negative breast cancer patient harboring ERBB3 (HER2) E928A who had previously progressed on several lines of therapy (PMID: 34250408). | 34250408 |