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Profile Name | FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG |
Gene Variant Detail |
FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG (gain of function - predicted) |
Relevant Treatment Approaches | FLT3 Inhibitor |
Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|---|
FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG | acute myeloid leukemia | sensitive | FLT3 Inhibitor | Tandutinib | Preclinical - Cell culture | Actionable | In a preclinical study, Tandutinib (CT53518) inhibited proliferation of cells expressing FLT3 G613_K614insYVDFREYEYDLKWEFRPRENLEFG in culture (PMID: 12124172). | 12124172 |