Molecular Profile Detail

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT02427893	Phase III	Cobimetinib Vemurafenib	Trial of Vemurafenib and Cobimetinib in Patients With Advanced BRAFV600 Mutant Melanoma	Withdrawn	USA	0
NCT03272464	Phase I	Dabrafenib + Itacitinib + Trametinib	INCB039110 in Combination With Dabrafenib and Trametinib in Patients With BRAF-mutant Melanoma and Other Solid Tumors.	Terminated	USA	0
NCT03551626	Phase III	Dabrafenib + Trametinib	Study of Dabrafenib+Trametinib in the Adjuvant Treatment of Stage III BRAF V600+ Melanoma After Complete Resection to Evaluate the Impact on Pyrexia Related Outcomes (COMBI-APlus)	Completed	TUR \| SWE \| SVN \| SVK \| POL \| NOR \| LVA \| LTU \| ITA \| ISR \| HUN \| GRC \| GBR \| FRA \| FIN \| CZE \| CAN \| BRA \| AUS \| ARG	3
NCT01682213	Phase II	Dabrafenib	Adjuvant Dabrafenib (GSK2118436) in Patients With Surgically Resected AJCC Stage IIIC Melanoma Characterized by a BRAFV600E/K Mutation	Completed	USA	0
NCT02097225	Phase I	Dabrafenib + Onalespib + Trametinib	Onalespib, Dabrafenib, and Trametinib in Treating Patients With BRAF-Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery	Terminated	USA	0
NCT02027961	Phase Ib/II	Dabrafenib + Durvalumab + Trametinib Durvalumab + Trametinib	Phase 1 Safety and Tolerability of MEDI4736 in Combination With Dabrafenib and Trametinib or With Trametinib Alone	Completed	USA \| ITA \| FRA \| CAN	0
NCT02196181	Phase II	Dabrafenib + Trametinib	Dabrafenib and Trametinib for the Treatment of Patients With Stage III-IV BRAF Mutant Melanoma That Cannot Be Removed by Surgery	Active, not recruiting	USA	0
NCT01495988	Phase II	Bevacizumab Vemurafenib	Trial of Vemurafenib With or Without Bevacizumab in Patients With Stage IV BRAFV600 Mutant Melanoma	Terminated	USA	0
NCT01781026	Phase II	Vemurafenib	Phase 2 Study of Neoadjuvant Vemurafenib in Melanoma Patients With Untreated Brain Metastases	Completed	USA	0
NCT01947023	Phase I	Dabrafenib + Lapatinib	Dabrafenib and Lapatinib in Treating Patients With Refractory Thyroid Cancer That Cannot Be Removed by Surgery	Active, not recruiting	USA	0
NCT01767454	Phase I	Dabrafenib + Ipilimumab + Trametinib Dabrafenib + Ipilimumab	Study of Dabrafenib +/- Trametinib in Combination With Ipilimumab for V600E/K Mutation Positive Metastatic or Unresectable Melanoma	Completed	USA	0
NCT04527549	Phase II	Dabrafenib + Trametinib Dabrafenib + Hydroxychloroquine + Trametinib	Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma	Terminated	USA	0
NCT02200562	Phase Ib/II	Dabrafenib + Ipilimumab	Ipilimumab and Dabrafenib in the 1st Line Tx of Unresectable Stage III/IV Melanoma	Terminated	USA	0
NCT01940809	Phase II	Dabrafenib + Ipilimumab Ipilimumab + Nivolumab + Trametinib Dabrafenib + Ipilimumab + Trametinib Ipilimumab + Trametinib Dabrafenib + Ipilimumab + Nivolumab Ipilimumab Ipilimumab + Nivolumab Dabrafenib + Ipilimumab + Nivolumab + Trametinib	Ipilimumab With or Without Dabrafenib, Trametinib, and/or Nivolumab in Treating Patients With Melanoma That Is Metastatic or Cannot Be Removed by Surgery	Terminated	USA	0
NCT03101254	Phase Ib/II	Cobimetinib + LY3022855 + Vemurafenib	LY3022855 With BRAF/MEK Inhibition in Patients With Melanoma	Completed	USA	0
NCT03455764	Phase Ib/II	Dabrafenib + MCS110 + Trametinib	MCS110 With BRAF/MEK Inhibition in Patients With Melanoma	Completed	USA	0
NCT01585415	Phase I	Vandetanib	Vemurafenib and White Blood Cell Therapy for Advanced Melanoma	Terminated	USA	0
NCT01978236	Phase II	Dabrafenib + Trametinib Dabrafenib	Dabrafenib/Trametinib, BRAF or BRAF AND MEK Pre-op With BRAF and MEK Post-op, Phase IIB, Melanoma With Brain Mets,Biomarkers and Metabolites	Terminated	USA \| AUS	0
NCT01657591	Phase I	Vemurafenib + XL888	Study of XL888 With Vemurafenib for Patients With Unresectable BRAF Mutated Stage III/IV Melanoma	Completed	USA	0
NCT02224781	Phase III	Ipilimumab + Nivolumab Dabrafenib + Trametinib	Dabrafenib and Trametinib Followed by Ipilimumab and Nivolumab or Ipilimumab and Nivolumab Followed by Dabrafenib and Trametinib in Treating Patients With Stage III-IV BRAFV600 Melanoma	Active, not recruiting	USA	0
NCT04655157	Phase Ib/II	Encorafenib + Ipilimumab + Nivolumab Binimetinib + Encorafenib + Ipilimumab + Nivolumab	Safety and Efficacy in Participants With Metastatic BRAF-mutant Melanoma Treated With Encorafenib With and Without Binimetinib in Combination With Nivolumab and Low-dose Ipilimuma (QUAD01)	Terminated	USA	0
NCT03026517	Phase I	Dabrafenib + Phenformin + Trametinib	Clinical Trial of Phenformin in Combination With BRAF Inhibitor + MEK Inhibitor for Patients With BRAF-mutated Melanoma	Completed	USA	0
NCT01682083	Phase III	Dabrafenib + Trametinib	Dabrafenib With Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma (COMBI-AD). (COMBI-AD)	Completed	USA \| SWE \| POL \| NZL \| NOR \| NLD \| ITA \| ISR \| GRC \| GBR \| FRA \| ESP \| DNK \| DEU \| CZE \| CHE \| CAN \| BRA \| BEL \| AUT \| AUS \| ARG	3
NCT01909453	Phase III	Vemurafenib Encorafenib Binimetinib + Encorafenib	Study Comparing Combination of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in BRAF Mutant Melanoma (COLUMBUS)	Completed	USA \| TUR \| SWE \| SVK \| POL \| NOR \| NLD \| ITA \| ISR \| HUN \| GRC \| GBR \| FRA \| ESP \| DEU \| CZE \| CHE \| CAN \| BRA \| AUS \| ARG	8
NCT01512251	Phase Ib/II	Buparlisib + Vemurafenib	BKM120 Combined With Vemurafenib (PLX4032) in BRAFV600E/K Mutant Advanced Melanoma	Completed	USA	0
NCT06079333	Phase II	Dabrafenib + Trametinib	NEO- and Adjuvant Targeted Therapy in Braf-mutated Anaplastic Cancer of the Thyroid (NEO-ATACT Study) (NEO-ATACT)	Recruiting	NLD	0
NCT02818023	Phase I	Cobimetinib + Pembrolizumab + Vemurafenib	Dose-seeking Study of Pembrolizumab Plus Vemurafenib and Cobimetinib Advanced Melanoma	Terminated	USA	0
NCT01989585	Phase Ib/II	Dabrafenib + Navitoclax + Trametinib Dabrafenib + Trametinib	Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma	Active, not recruiting	USA	0

Profile Name	BRAF V600E/K
Gene Variant Detail	BRAF V600E/K (gain of function)
Relevant Treatment Approaches	BRAF Inhibitor MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor RAF Inhibitor (Pan)

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