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| Profile Name | PALB2 del PALB2 mut |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| PALB2 del PALB2 mut | prostate cancer | predicted - sensitive | Olaparib | Case Reports/Case Series | Actionable | In a Phase II study (TOPARP-A), a patient with metastatic castration-resistant prostate cancer harboring a frameshift PALB2 mutation together with a heterozygous PALB2 deletion achieved a response to Lynparza (olaparib) that lasted for 39 weeks (PMID: 26510020; NCT01682772). | 26510020 |