Molecular Profile Detail

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Profile Name MDM2 pos TP53 R248Q TP53 R267L TP53 R273H
Gene Variant Detail

MDM2 positive (unknown)

TP53 R248Q (loss of function)

TP53 R267L (unknown)

TP53 R273H (loss of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
MDM2 pos TP53 R248Q TP53 R267L TP53 R273H triple-receptor negative breast cancer sensitive YX-02-030 Preclinical - Patient cell culture Actionable In a preclinical study, YX-02-030 decreased Mdm2 expression and increased apoptosis in patient-derived triple-negative breast cancer explants harboring TP53 R248Q, R267L, and R273H in culture (PMID: 36734633). 36734633