Molecular Profile Detail

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Profile Name FLT3 D835K FLT3 D835L
Gene Variant Detail

FLT3 D835K (gain of function - predicted)

FLT3 D835L (gain of function - predicted)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 D835K FLT3 D835L hematologic cancer sensitive Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) inhibited Flt3 autophosphorylation and viability in transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer sensitive Lestaurtinib Preclinical - Cell culture Actionable In a preclinical study, Lestaurtinib (CEP-701) inhibited Flt3 autophosphorylation and viability in transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit AG1295 Preclinical - Cell culture Actionable In a preclinical study, AG1295 did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit Linifanib Preclinical - Cell culture Actionable In a preclinical study, Linifanib (ABT-869) did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit Quizartinib Preclinical - Cell culture Actionable In a preclinical study, Vanflyta (quizartinib) did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit Sunitinib Preclinical - Cell culture Actionable In a preclinical study, Sutent (sunitinib) did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit Sorafenib Preclinical - Cell culture Actionable In a preclinical study, Nexavar (sorafenib) did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit Tamatinib Preclinical - Cell culture Actionable In a preclinical study, Tamatinib (R406) did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit KW-2449 Preclinical - Cell culture Actionable In a preclinical study, KW-2449 did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit Crenolanib Preclinical - Cell culture Actionable In a preclinical study, Crenolanib (CP-868596) did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790
FLT3 D835K FLT3 D835L hematologic cancer no benefit Ponatinib Preclinical - Cell culture Actionable In a preclinical study, Iclusig (ponatinib) did not inhibit viability of transformed cells expressing FLT3 D835L and D835K in culture (PMID: 28077790). 28077790