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| Profile Name | BTK E108K BTK T474I BTK C481S BTK L528W |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| BTK E108K BTK T474I BTK C481S BTK L528W | chronic lymphocytic leukemia | predicted - resistant | Tirabrutinib | Case Reports/Case Series | Actionable | In Phase I trials, a patient with chronic lymphocytic leukemia progressed on treatment with Tirabrutinib (ONO-4059) and was subsequently found to have acquired BTK C481S, T474I, L528W, and E108K (PMID: 37257190; NCT01659255 and NCT02457598). | 37257190 |