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| Profile Name | BRAF V600E MAP2K1 S194P |
| Gene Variant Detail | |
| Relevant Treatment Approaches |
| Molecular Profile | Indication/Tumor Type | Response Type | Relevant Treatment Approaches | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|---|
| BRAF V600E MAP2K1 S194P | colorectal cancer | resistant | Cetuximab + Dabrafenib | Preclinical - Cell culture | Actionable | In a preclinical study, Tafinlar (dabrafenib) and Erbitux (cetuximab) combination treatment inhibited senescence in a colorectal cancer cell line harboring BRAF V600E and expressing MAP2K1 S194P in culture (PMID: 39424923). | 39424923 |