Molecular Profile Detail

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Profile Name ATM R3008H KIT V559D KIT D579del KIT D820Y KIT A829P
Gene Variant Detail

ATM R3008H (loss of function)

KIT A829P (gain of function)

KIT D579del (gain of function)

KIT D820Y (gain of function)

KIT V559D (gain of function)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM R3008H KIT V559D KIT D579del KIT D820Y KIT A829P gastrointestinal stromal tumor predicted - sensitive Olaparib + Ripretinib Case Reports/Case Series Actionable In a clinical case study, treatment with the combination of Lynparza (olaparib) and Qinlock (ripretinib) resulted in stable disease with a progression-free survival of 6.2 months in a patient with recurrent gastrointestinal stromal tumor harboring KIT V559D, D579del, D820Y, and A829P and ATM R3008H (PMID: 40700673; NCT0253467). 40700673