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Profile Name | TP53 R175H |
Gene Variant Detail | |
Relevant Treatment Approaches | p53 Activator p53 Gene Therapy |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT05877599 | Phase I | NT-175 | A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation | Recruiting | USA | 0 |
NCT06778863 | Phase I | A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation (GUARDIAN-101) | Recruiting | USA | 0 | |
NCT06690281 | Phase II | Cyclophosphamide + Fludarabine Aldesleukin + Autologous KRAS mutant TCR-transduced PBLs | A Phase II Study of Adjuvant Immunotherapy Targeting KRAS G12D, KRAS G12V, or TP53 R175H for Participants With Advanced Gastrointestinal Malignancies | Not yet recruiting | USA | 0 |