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| Molecular Profile | AXL over exp |
| Therapy | RXDX-106 |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| AXL over exp | Advanced Solid Tumor | sensitive | RXDX-106 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, RXDX-106 inhibited Tam-family kinases activity in transformed cells over expressing Axl in culture, resulted in tumor growth inhibition in cell line xenograft models (Eur J Cancer, Vol 69, Supplement 1, December 2016, Page S31). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Immuno-oncologic efficacy of RXDX-106, a selective, TAM family small molecule kinase inhibitor | Full reference... |