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| Ref Type | Journal Article | ||||||||||||
| PMID | (38579194) | ||||||||||||
| Authors | Hoff CO, Dal Lago EA, Siqueira JM, de Sousa LG, El-Naggar AK, Ahnert JR, Ferrarotto R | ||||||||||||
| Title | First Use of AXL Targeting in Metastatic, Refractory, Adenoid Cystic Carcinoma: A Case Report. | ||||||||||||
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| Abstract Text | First use of AXL-targeting in adenoid cystic carcinoma (ACC); with positive results, ACC now included in AXL studies. | ||||||||||||
| Molecular Profile | Treatment Approach |
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| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| AXL over exp | adenoid cystic carcinoma | predicted - sensitive | Mecbotamab Vedotin | Case Reports/Case Series | Actionable | In a Phase I trial, Mecbotamab Vedotin treatment resulted in stable disease with radiological and clinical improvement in a patient with adenoid cystic carcinoma with high AXL expression (PMID: 38579194; NCT03425279). | 38579194 |