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Ref Type Journal Article
PMID (38579194)
Authors Hoff CO, Dal Lago EA, Siqueira JM, de Sousa LG, El-Naggar AK, Ahnert JR, Ferrarotto R
Title First Use of AXL Targeting in Metastatic, Refractory, Adenoid Cystic Carcinoma: A Case Report.
URL
Abstract Text First use of AXL-targeting in adenoid cystic carcinoma (ACC); with positive results, ACC now included in AXL studies.

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Molecular Profile Treatment Approach
Gene Name Source Synonyms Protein Domains Gene Description Gene Role
Therapy Name Drugs Efficacy Evidence Clinical Trials
Drug Name Trade Name Synonyms Drug Classes Drug Description
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
AXL over exp adenoid cystic carcinoma predicted - sensitive Mecbotamab Vedotin Case Reports/Case Series Actionable In a Phase I trial, Mecbotamab Vedotin treatment resulted in stable disease with radiological and clinical improvement in a patient with adenoid cystic carcinoma with high AXL expression (PMID: 38579194; NCT03425279). 38579194