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| Ref Type | Journal Article | ||||||||||||
| PMID | (38781546) | ||||||||||||
| Authors | Tanaka R, Mrachek K, Arocho-Quinones E, Carlberg VM, Smith C, Kurzrock R, Deshmukh T | ||||||||||||
| Title | Dabrafenib for Pilocytic Astrocytoma With BRAF V599ins. | ||||||||||||
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| Abstract Text | This report highlights the first pediatric case of pilocytic astrocytoma with BRAF V599ins mutation, successfully treated with dabrafenib. | ||||||||||||
| Molecular Profile | Treatment Approach |
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| Gene Name | Source | Synonyms | Protein Domains | Gene Description | Gene Role |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
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| Gene | Variant | Impact | Protein Effect | Variant Description | Associated with drug Resistance |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF A598_T599insV | pilocytic astrocytoma | predicted - sensitive | Dabrafenib | Case Reports/Case Series | Actionable | In a clinical case study, Tafinlar (dabrafenib) resulted in neurological improvement and decreased tumor size after 3 months of treatment in a pediatric patient with pilocytic astrocytoma harboring BRAF A598_T599insV (reported as BRAF V599ins) (PMID: 38781546). | 38781546 |