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Ref Type Journal Article
PMID (23792360)
Authors Yao HP, Zhou YQ, Zhang R, Wang MH
Title MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Journal Vol Issue Date Pages Journal Short Title
Nature reviews. Cancer 13 7 2013 Jul 466-81 Nat Rev Cancer
URL
Abstract Text Since the discovery of MSP (macrophage-stimulating protein; also known as MST1 and hepatocyte growth factor-like (HGFL)) as the ligand for the receptor tyrosine kinase RON (also known as MST1R) in the early 1990s, the roles of this signalling axis in cancer pathogenesis has been extensively studied in various model systems. Both in vitro and in vivo evidence has revealed that MSP-RON signalling is important for the invasive growth of different types of cancers. Currently, small-molecule inhibitors and antibodies blocking RON signalling are under investigation. Substantial responses have been achieved in human tumour xenograft models, laying the foundation for clinical validation. In this Review, we discuss recent advances that demonstrate the importance of MSP-RON signalling in cancer and its potential as a therapeutic target.

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Gene Name Source Synonyms Protein Domains Gene Description Gene Role
MST1R NCBI CD136|CDw136|NPCA3|p185-Ron|PTK8|RON|SEA MST1R, macrophage stimulating 1 receptor, encodes the receptor tyrosine kinase RON, which acts as a receptor for macrophage-stimulating protein and is involved in cell migration and differentiation (PMID: 21543897, PMID: 23792360). Alterations in MST1R have been associated with several tumor types (PMID: 23792360) and overexpression of Mst1r has been associated with pancreatic cancer progression (PMID: 30967626). Unknown
Therapy Name Drugs Efficacy Evidence Clinical Trials
MK8033 MK8033 0 0
Drug Name Trade Name Synonyms Drug Classes Drug Description
MK8033 MK-8033|HQP8361|HQP 8361|HQP-8361|MK 8033 MET Inhibitor 59 RON Inhibitor 11 MK8033 is an inhibitor of MET and MST1R (RON) that suppresses mTOR signaling, potentially resulting in reduced survival and colony formation, increased apoptosis, and inhibition of tumor growth (PMID: 23792360, PMID: 33163272).
Gene Variant Impact Protein Effect Variant Description Associated with drug Resistance
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References