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Therapy Detail

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Therapy Name DPV-001 + INCAGN01876 + Retifanlimab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DPV-001 DPV 001|DPV001 DPV-001 is a cancer vaccine consisting of dendritic cell targeting microvesicles (DRibbles), which are autophagosomes derived from two non-small cell lung carcinoma cell lines (UbiLT3 and UbiLT6) that contain numerous tumor-associated antigens, including DAMPs, and delivers stable short-lived proteins (SLiPs) and defective ribosomal products (DRiPs), potential resulting in the induction of antitumor immune response (JITC 2015; 3(Suppl 2): P435; JITC 2013; 1(Suppl 1): P260).
INCAGN01876 INCAGN1876|INCAGN-1876|INCAGN 1876 GITR Antibody 7 INCAGN01876 is an activating monoclonal antibody that binds to the glucocorticoid-induced tumor necrosis factor receptor, TNFRSF18 (GITR, CD357), which leads to activation of GITR and potentially results in activation of anti-tumor immunity (NCI Drug Dictionary).
Retifanlimab Zynyz MGA 012|INCMGA00012|MGA012|retifanlimab-dlwr Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 124 Zynyz (retifanlimab) is a humanized IgG4 monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT085). Zynyz (retifanlimab) is FDA approved for use in adult patients with metastatic or recurrent locally advanced Merkel cell carcinoma (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04470024 Phase I DPV-001 + INCAGN01876 + Retifanlimab DPV-001 + Retifanlimab Phase Ib Trial of Multivalent Autophagosome Vaccine With or Without GITR Agonist, With Anti-PD-1 Immunotherapy in HNSCC Recruiting USA 0


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