Retifanlimab
Drug Detail
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| Drug Name | Retifanlimab |
| Trade Name | Zynyz |
| Synonyms | MGA 012|INCMGA00012|MGA012|retifanlimab-dlwr |
| Drug Descriptions |
Zynyz (retifanlimab) is a humanized IgG4 monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr CT085). Zynyz (retifanlimab) is FDA approved for use in adult patients with metastatic or recurrent locally advanced Merkel cell carcinoma, and in combination with Paraplatin (carboplatin) and Taxol (paclitaxel) or as a single agent for patients with anal canal squamous cell carcinoma (FDA.gov). |
| DrugClasses | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 130 |
| CAS Registry Number | 2226345-85-1 |
| NCIT ID | C142168 |
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