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Therapy Name	Lucitanib
Synonyms
Therapy Description	Lucitanib (E-3810) is a multi-tyrosine kinase receptor inhibitor of VEGFR 1-3, DDR2, PDGFRA, and FGFR1-2, that may inhibit tumor angiogenesis, prevent tumor cell proliferation, and induce tumor cell death (PMID: 27988457, PMID: 24696502, PMID: 31619444).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Lucitanib		E-3810\|AL3810	DDR1 Inhibitor 10 DDR2 inhibitor 7 FGFR1 Inhibitor 28 FGFR2 Inhibitor 24 PDGFR-alpha Inhibitor 10 VEGFR Inhibitor (Pan) 36	Lucitanib (E-3810) is a multi-tyrosine kinase receptor inhibitor of VEGFR 1-3, DDR2, PDGFRA, and FGFR1-2, that may inhibit tumor angiogenesis, prevent tumor cell proliferation, and induce tumor cell death (PMID: 27988457, PMID: 24696502, PMID: 31619444).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FGFR1 amp	Her2-receptor negative breast cancer	predicted - sensitive	Lucitanib	Phase II	Actionable	In a Phase II (FINESSE) trial, Lucitanib (E-3810) treatment resulted in an objective response rate (ORR) of 19% (6/32) and a clinical benefit rate of 41% (13/32) in patients with metastatic hormone receptor-positive, Erbb2 (Her2)-negative breast cancer harboring FGFR1 amplification, ORR was improved (22%, 5/23 vs 9%, 5/53) in patients with high level FGFR1 amplification (FGFR1/centromere ratio>=4) compared to those without (PMID: 31619444; NCT02053636).	31619444
FGFR1 over exp	Her2-receptor negative breast cancer	predicted - sensitive	Lucitanib	Phase II	Actionable	In a Phase II (FINESSE) trial, Lucitanib (E-3810) treatment resulted in improved objective response rate (25%, 5/20 vs 8%, 3/39) and median progression-free survival (158 vs 109 days) in patients with metastatic hormone receptor-positive, Erbb2 (Her2)-negative breast cancer with high Fgfr1 expression (H-score>=50) compared to those with low Fgfr1 expression (H-score<50) (PMID: 31619444; NCT02053636).	31619444
FGFR1 amp	triple-receptor negative breast cancer	predicted - sensitive	Lucitanib	Preclinical - Pdx	Actionable	In a preclinical study, Lucitanib (E-3810) treatment resulted in reduced tumor volume in FGFR1-amplified triple-negative breast cancer patient-derived xenograft (PDX) models (PMID: 34593528).	34593528
FGFR1 W4C FGFR1 amp	estrogen-receptor positive breast cancer	predicted - sensitive	Lucitanib	Preclinical - Pdx	Actionable	In a preclinical study, Lucitanib (E-3810) treatment resulted in reduced tumor volume in an ER-positive breast cancer patient-derived xenograft (PDX) model harboring FGFR1 W4C and FGFR1 amplification (PMID: 34593528).	34593528
FGFR1 amp	lung carcinoma	sensitive	Lucitanib	Preclinical - Cell line xenograft	Actionable	in a preclinical study, Lucitanib (E-3810) preferentially inhibited growth of FGFR1-amplified lung carcinoma cell lines in culture and in cell line xenograft models (PMID: 27988457).	27988457
FGFR1 amp	estrogen-receptor positive breast cancer	sensitive	Lucitanib	Preclinical - Cell culture	Actionable	In a preclinical study, an estrogen-receptor positive breast cancer cell line harboring FGFR1 amplification demonstrated sensitivity to treatment with Lucitanib (E-3810) in culture (PMID: 27126994).	27126994

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT01283945	Phase Ib/II	Lucitanib	Study of Oral Lucitanib (E-3810), a Dual VEGFR-FGFR Tyrosine Kinase Inhibitor, in Patients With Solid Tumors	Completed	ITA \| FRA \| ESP	0
NCT02053636	Phase II	Lucitanib	A Phase II Trial Testing Oral Administration of Lucitanib in Patients With Fibroblast Growth Factor Receptor (FGFR)1-amplified or Non-amplified Estrogen Receptor Positive Metastatic Breast Cancer	Completed	ITA \| HUN \| GBR \| FRA \| ESP \| DEU \| CAN \| BEL \| AUS	0
NCT02109016	Phase II	Lucitanib	A Study to Assess the Efficacy of the VEGFR-FGFR Inhibitor, Lucitanib, Given to Patients With FGFR1-driven Lung Cancer	Terminated	USA \| ITA \| FRA \| ESP \| DEU	0
NCT02202746	Phase II	Lucitanib	A Study to Assess the Safety and Efficacy of the VEGFR-FGFR Inhibitor, Lucitanib, Given to Patients With FGF Aberrant Metastatic Breast Cancer	Terminated	USA	0
NCT02747797	Phase II	Lucitanib	Lucitanib (E3810) in Patients With Advanced Cancer and FGFR, VEGFR, or PDGFR Pathway Aberrations	Withdrawn	USA	0

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