Therapy Detail

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Therapy Name Capecitabine + DKN-01 + Oxaliplatin + Tislelizumab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Capecitabine Xeloda R340 Chemotherapy - Antimetabolite 14 Xeloda (capecitabine) is an antimetabolite that when activated to 5-FU ultimately inhibits DNA synthesis and cell division (NCI Drug Dictionary).
DKN-01 DKN 01|DKN01 WNT Inhibitor 16 DKN-01 is a monoclonal antibody that binds to and inhibits Dkk1, a Wnt receptor antagonist, resulting in restoration of Wnt signaling and tumor growth inhibition (PMID: 28731148, PMID: 32192732).
Oxaliplatin Eloxatin Diaminocyclohexane Oxalatoplatinum Chemotherapy - Platinum 7 Eloxatin (oxaliplatin) is comprised of a platinum complex, which causes DNA-platinum cross-links, inhibition of DNA replication and transcription, and cell toxicity, and is FDA approved for colorectal cancer (FDA.gov).
Tislelizumab Tevimbra BGB-A317|tislelizumab-jsgr Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Tevimbra (tislelizumab) is a human monoclonal antibody that targets PD-1 (PDCD1), thereby blocking the binding of PD-L1 (CD274) and potentially resulting in activation of a T-cell immune response against tumor cells (PMID: 32769013, PMID: 32561638, PMID: 32540858). Tevimbra (tislelizumab) is FDA-approved for use in patients with unresectable or metastatic esophageal squamous cell carcinoma (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04363801 Phase II DKN-01 + Tislelizumab Capecitabine + DKN-01 + Oxaliplatin + Tislelizumab A Study of DKN-01 in Combination With Tislelizumab ± Chemotherapy in Patients With Gastric or Gastroesophageal Cancer (DisTinGuish) Active, not recruiting USA | DEU 1


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