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Drug Name | DKN-01 |
Trade Name | |
Synonyms | DKN 01|DKN01 |
Drug Descriptions |
DKN-01 is a monoclonal antibody that binds to and inhibits Dkk1, a Wnt receptor antagonist, resulting in restoration of Wnt signaling and tumor growth inhibition (PMID: 28731148, PMID: 32192732). |
DrugClasses | WNT Inhibitor 16 |
CAS Registry Number | NA |
NCIT ID | C113331 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Atezolizumab + DKN-01 | Atezolizumab DKN-01 | 0 | 1 |
Capecitabine + DKN-01 + Oxaliplatin + Tislelizumab | Capecitabine DKN-01 Oxaliplatin Tislelizumab | 0 | 1 |
DKN-01 | DKN-01 | 0 | 3 |
DKN-01 + Docetaxel | DKN-01 Docetaxel | 0 | 1 |
DKN-01 + Fluorouracil + Irinotecan + Leucovorin | DKN-01 Fluorouracil Irinotecan Leucovorin | 0 | 1 |
DKN-01 + Nivolumab | DKN-01 Nivolumab | 0 | 1 |
DKN-01 + Paclitaxel | DKN-01 Paclitaxel | 0 | 2 |
DKN-01 + Pembrolizumab | DKN-01 Pembrolizumab | 0 | 1 |
DKN-01 + Sorafenib | DKN-01 Sorafenib | 0 | 0 |
DKN-01 + Tislelizumab | DKN-01 Tislelizumab | 0 | 1 |