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Therapy Name MCY-M11
Synonyms
Therapy Description

MCY-M11 consists of autologous peripheral blood mononuclear cells modified to express an mRNA construct that encodes a mesothelin-targeting chimeric antigen receptor (CAR), which potentially induces phagocytosis and increases cytotoxicity against tumor cells expressing mesothelin (NCI Drug Dictionary; J Clin Oncol 2020 38:15_suppl, 3014).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MCY-M11 anti-mesothelin mRNA-transfected autologous PBMCs MCY-M11 MCY-M11 consists of autologous peripheral blood mononuclear cells modified to express an mRNA construct that encodes a mesothelin-targeting chimeric antigen receptor (CAR), which potentially induces phagocytosis and increases cytotoxicity against tumor cells expressing mesothelin (NCI Drug Dictionary; J Clin Oncol 2020 38:15_suppl, 3014).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03608618 Phase I MCY-M11 Cyclophosphamide Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma Terminated USA 0


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