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Therapy Name Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells + Iomab-B
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells Autologous CD19 CAR+ EGFRt + CD4+ and CD8+ T cells CD19 Immune Cell Therapy 62 Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells comprise CD4- and CD8-positive autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) containing an anti-CD19 fragment linked to the CD28 and CD3zeta signaling domains and a truncated human epidermal growth factor receptor (EGFRt), which potentially induce cytotoxicity against CD19-expressing tumor cells and antitumor activity (PMID: 28408462, NCI Drug Dictionary).
Iomab-B I 131 MOAB BC8|131-I Apamistamab|Iodine I 131-apamistamab Iomab-B (131-I apamistamab) comprises an antibody targeting CD45 conjugated to iodine 131 (I-131), which delivers I-131 to CD45-expressing cells, potentially resulting in increased death of CD45-expressing tumor cells (NCI Drug Dictionary).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04512716 Phase I Anti-CD19CAR-CD28-CD3zeta-EGFRt T-cells + Iomab-B Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma Recruiting USA 0


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