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Therapy Name FPI-2265
Synonyms
Therapy Description

FPI-2265 is a radioconjugate comprising the radionuclide actinium-225 linked to a monoclonal antibody that targets PSMA, which delivers radiation to PSMA-expressing tumor cells, potentially resulting in antitumor activity (Cancer Res (2024) 84 (7_Supplement): CT224).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
FPI-2265 FPI 2265|FPI2265|225Ac-PSMA-I&T FPI-2265 is a radioconjugate comprising the radionuclide actinium-225 linked to a monoclonal antibody that targets PSMA, which delivers radiation to PSMA-expressing tumor cells, potentially resulting in antitumor activity (Cancer Res (2024) 84 (7_Supplement): CT224).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05219500 Phase II FPI-2265 Targeted Alpha Therapy With 225Actinium-Prostate Specific Membrane Antigen (PSMA)-I&T of Castration-resISTant Prostate Cancer (TATCIST). (TATCIST) Recruiting USA 0
NCT06402331 Phase II FPI-2265 FPI-2265 (225Ac-PSMA-I&T) for Patients With PSMA-Positive Metastatic Castration-Resistant Prostate Cancer (mCRPC) (AlphaBreak) Recruiting USA 0


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