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Therapy Detail
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| Therapy Name | TG-1801 + Ublituximab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TG-1801 | NI-1701|TG1801|TG 1801 | CD19 Antibody 21 CD47 Antibody 31 Immune Checkpoint Inhibitor 149 | TG-1801 (NI-1701) is a bispecific antibody that binds to CD47 and CD19 on B cells and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, potentially leading increased antitumor immune response and phagocytosis of tumor cells (PMID: 29743205, PMID: 35538512). | |
| Ublituximab | LFB-R603|TG-1101|TG-20|TGTX-1101 | CD20 Antibody 25 | Ublituximab (TG-1101) is a monoclonal antibody that targets CD20 that may induce complement-dependent and antibody-dependent cell-mediated cytotoxicity against B-cells expressing CD20, potentially resulting in increased B-cell death (PMID: 23611989, PMID: 32351164). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT03804996 | Phase I | TG-1801 + Ublituximab TG-1801 | Study of TG-1801 in Subjects With B-Cell Lymphoma | Completed | AUS | 0 |
| NCT04806035 | Phase I | TG-1801 + Ublituximab TG-1801 | Study of TG-1801 Alone or in Combination With Ublituximab in Subjects With B-Cell Lymphoma or Chronic Lymphocytic Leukemia | Terminated | USA | 0 |
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