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Therapy Name | Ivonescimab |
Synonyms | |
Therapy Description |
Ivonescimab is a bispecific antibody that binds PD-1 and VEGFA, potentially resulting in antitumor activity (PMID: 37593227). |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Ivonescimab | AK112|AK 112|AK-112|SMT112|SMT 112|SMT-112 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 VEGFA Antibody 4 | Ivonescimab is a bispecific antibody that binds PD-1 and VEGFA, potentially resulting in antitumor activity (PMID: 37593227). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT04047290 | Phase I | Ivonescimab | A Study of AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors | Unknown status | AUS | 0 |
NCT06529718 | Phase II | Fluorouracil + Leucovorin + Oxaliplatin Ivonescimab | Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients (SEVILLA) | Not yet recruiting | GBR | FRA | BEL | 0 |
NCT06567314 | Phase II | Ivonescimab | Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma | Not yet recruiting | USA | 0 |
NCT06672575 | Phase Ib/II | Ivonescimab | A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma | Not yet recruiting | USA | 0 |
NCT05899608 | Phase III | Pembrolizumab Ivonescimab | Clinical Study of Ivonescimab for First-line Treatment of Metastatic Squamous NSCLC Patients | Recruiting | USA | CAN | 0 |