Therapy Detail

Request Content

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Therapy Name Ivonescimab
Synonyms
Therapy Description

Ivonescimab is a bispecific antibody that binds PD-1 and VEGFA, potentially resulting in antitumor activity (PMID: 37593227).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Drug Name Trade Name Synonyms Drug Classes Drug Description
Ivonescimab AK112|AK 112|AK-112|SMT112|SMT 112|SMT-112 Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 VEGFA Antibody 5 Ivonescimab is a bispecific antibody that binds PD-1 and VEGFA, potentially resulting in antitumor activity (PMID: 37593227).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06940518 Phase II Ivonescimab Phase II Trial of Ivonescimab in Previously Treated Patients With Advanced Clear Cell Renal Cell Carcinoma Recruiting USA 0
NCT06567314 Phase II Ivonescimab Phase 2 Study of Ivonescimab in Patients With Cutaneous Squamous Cell Carcinoma Recruiting USA 0
NCT06925724 Phase II Ivonescimab A Study of Ivonescimab in People With Endometrial and Cervical Cancers Recruiting USA 0
NCT05899608 Phase III Pembrolizumab Ivonescimab Clinical Study of Ivonescimab for First-line Treatment of Metastatic Squamous NSCLC Patients Recruiting USA | SWE | POL | ITA | IRL | GRC | GBR | FRA | ESP | DEU | CAN | BEL 4
NCT06529718 Phase II Fluorouracil + Leucovorin + Oxaliplatin Ivonescimab Testing Ivonescimab Versus FOLFOX in Advanced Biliary Tract Cancer Patients (SEVILLA) Recruiting GBR | FRA 0
NCT04047290 Phase I Ivonescimab A Study of AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors Completed AUS 0
NCT06672575 Phase Ib/II Ivonescimab A Phase I/II Study of IVONESCIMAB in Recurrent Glioblastoma Recruiting USA 0
NCT06980077 Phase II Ivonescimab Ivonescimab for the Treatment of Thymic Cancer Recruiting USA 0
NCT06767514 Phase III Pembrolizumab Ivonescimab Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1 (HARMONi-7) Recruiting USA | TUR | ROU | POL | ITA | GRC | FRA | ESP | DEU | CAN 3
NCT06840834 Phase II Ivonescimab Evaluating Ivonescimab As a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and Chemotherapy (Bi-MAPS) Recruiting FRA 0
NCT06805617 Phase II Ivonescimab A Phase 2 Trial of Ivonescimab for Patients With Advanced, Metastatic Salivary Gland Cancers (I-MAC) Recruiting USA 0
NCT05382442 Phase II Ivonescimab Fluorouracil + Ivonescimab + Leucovorin + Oxaliplatin AK117 + Fluorouracil + Irinotecan + Ivonescimab + Leucovorin + Oxaliplatin AK117 + Fluorouracil + Ivonescimab + Leucovorin AK117 + Capecitabine + Ivonescimab + Oxaliplatin AK117 + Capecitabine + Ivonescimab Fluorouracil + Ivonescimab + Leucovorin AK117 + Ivonescimab Capecitabine + Ivonescimab + Oxaliplatin Fluorouracil + Irinotecan + Ivonescimab + Leucovorin + Oxaliplatin A Study of AK112 With or Without AK117 in Metastatic Colorectal Cancer Active, not recruiting USA 1
NCT06959550 Phase II Ivonescimab Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer Recruiting USA 0
NCT07094685 Phase II Ivonescimab Ivonescimab Before Surgery for the Treatment of Resectable Stage II-IV Head and Neck Cancer (SENIOR-HN) Recruiting USA 0


Additional content available in Icon for CKB-BoostCKB BOOST