Therapy Detail
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| Therapy Name | Tazemetostat + Ublituximab + Umbralisib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Tazemetostat | Tazverik | EPZ6438|E-7438|EPZ-6438 | EZH2 inhibitor 20 | Tazverik (tazemetostat) binds to and inhibits EZH2, resulting in decreased tri-methylation of H3K27, which potentially leads to inhibition of cell proliferation and tumor growth (PMID: 23620515). |
| Ublituximab | LFB-R603|TG-1101|TG-20|TGTX-1101 | CD20 Antibody 28 | Ublituximab (TG-1101) is a monoclonal antibody that targets CD20 that may induce complement-dependent and antibody-dependent cell-mediated cytotoxicity against B-cells expressing CD20, potentially resulting in increased B-cell death (PMID: 23611989, PMID: 32351164). | |
| Umbralisib | Ukoniq | RP5264|TGR-1202 | PIK3CD inhibitor 27 | Ukoniq (umbralisib) inhibits PIK3CD and Casein Kinase 1 epsilon (CK1e), which decreases Akt phosphorylation and potentially reduces tumor cell viability (PMID: 33617893, PMID: 32634240, PMID: 30709431). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05152459 | Phase Ib/II | Tazemetostat + Ublituximab + Umbralisib | Tazemetostat in Combination With Umbralisib and Ublituximab for the Treatment Relapsed or Refractory Follicular Lymphoma | Withdrawn | 0 |
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