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| Drug Name | Tazemetostat |
| Trade Name | Tazverik |
| Synonyms | EPZ6438|E-7438|EPZ-6438 |
| Drug Descriptions |
Tazverik (tazemetostat) binds to and inhibits EZH2, resulting in decreased tri-methylation of H3K27, and potentially leading to inhibition of cell proliferation and tumor growth (PMID: 23620515). Tazverik (tazemetostat) is FDA approved for use in patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection, and in adult patients with relapsed or refractory follicular lymphoma (R/R FL) harboring an EZH2 mutation after 2 prior therapies, and in patients with R/R FL without treatment options (FDA.gov). |
| DrugClasses | EZH2 inhibitor 20 |
| CAS Registry Number | 1403254-99-8 |
| NCIT ID | C107506 |
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