Therapy Detail
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| Therapy Name | Acalabrutinib + AZD0466 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD0466 | AZD-0466|AZD 0466 | BCL-XL inhibitor 14 BCL2 inhibitor 27 | AZD0466 is a nanoparticle comprised of the BH3 mimetic AZD4320 linked to a pegylated poly-lysine dendrimer, which is cleaved to release AZD4320, leading to inhibition of BCL-XL and BCL2, and potentially resulting in increased tumor cell apoptosis and decreased tumor growth (PMID: 34050131). | |
| Acalabrutinib | Calquence | ACP-196 | BTK inhibitor 37 | Calquence (acalabrutinib) selectively inhibits BTK, resulting in decreased B-cell receptor signaling, and potentially leading to decreased tumor cell proliferation (PMID: 27903679, PMID: 26957112). Calquence (acalabrutinib) is FDA approved for use in patients with mantle cell lymphoma, chronic lymphocytic leukemia or small lymphocytic lymphoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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