Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Drug Name | AZD0466 |
Trade Name | |
Synonyms | AZD-0466|AZD 0466 |
Drug Descriptions |
AZD0466 is a nanoparticle comprised of the BH3 mimetic AZD4320 linked to a pegylated poly-lysine dendrimer, which is cleaved to release AZD4320, leading to inhibition of BCL-XL and BCL2, and potentially resulting in increased tumor cell apoptosis and decreased tumor growth (PMID: 34050131). |
DrugClasses | BCL-XL inhibitor 14 BCL2 inhibitor 27 |
CAS Registry Number | NA |
NCIT ID | C173660 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Acalabrutinib + AZD0466 | AZD0466 Acalabrutinib | 0 | 0 |
AZD0466 | AZD0466 | 0 | 3 |
AZD0466 + Cisplatin | AZD0466 Cisplatin | 0 | 0 |
AZD0466 + Voriconazole | AZD0466 Voriconazole | 0 | 1 |