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Drug Name AZD0466
Trade Name
Synonyms AZD-0466|AZD 0466
Drug Descriptions

AZD0466 is a nanoparticle comprised of the BH3 mimetic AZD4320 linked to a pegylated poly-lysine dendrimer, which is cleaved to release AZD4320, leading to inhibition of BCL-XL and BCL2, and potentially resulting in increased tumor cell apoptosis and decreased tumor growth (PMID: 34050131).

DrugClasses BCL-XL inhibitor 14 BCL2 inhibitor 27
CAS Registry Number NA
NCIT ID C173660

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Acalabrutinib + AZD0466 AZD0466 Acalabrutinib 0 0
AZD0466 AZD0466 0 3
AZD0466 + Cisplatin AZD0466 Cisplatin 0 0
AZD0466 + Voriconazole AZD0466 Voriconazole 0 1


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