AZD0466
Drug Detail
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| Drug Name | AZD0466 |
| Trade Name | |
| Synonyms | AZD-0466|AZD 0466 |
| Drug Descriptions |
AZD0466 is a nanoparticle comprised of the BH3 mimetic AZD4320 linked to a pegylated poly-lysine dendrimer, which is cleaved to release AZD4320, leading to inhibition of BCL-XL and BCL2, and potentially resulting in increased tumor cell apoptosis and decreased tumor growth (PMID: 34050131). |
| DrugClasses | BCL-XL inhibitor 14 BCL2 inhibitor 29 |
| CAS Registry Number | NA |
| NCIT ID | C173660 |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Acalabrutinib + AZD0466 | AZD0466 Acalabrutinib | 0 | 0 |
| AZD0466 | AZD0466 | 0 | 3 |
| AZD0466 + Cisplatin | AZD0466 Cisplatin | 0 | 0 |
| AZD0466 + Voriconazole | AZD0466 Voriconazole | 0 | 1 |
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