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Therapy Name MVC-101
Synonyms
Therapy Description

MVC-101 is a bispecific T cell engager that targets EGFR expressed on tumor cells and CD3 antigen found on T cells, which upon proteolytic cleavage of the linker potentially leads to T cell activation against tumor cells and subsequent tumor regression (PMID: 32684124).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
MVC-101 MVC 101|MVC101|TAK 186|TAK-186|TAK186 CD3 Antibody 99 EGFR Antibody 60 MVC-101 is a bispecific T cell engager that targets EGFR expressed on tumor cells and CD3 antigen found on T cells, which upon proteolytic cleavage of the linker potentially leads to T cell activation against tumor cells and subsequent tumor regression (PMID: 32684124).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04844073 Phase Ib/II MVC-101 A Dose Escalation and Expansion Study of MVC-101 in Patients With Advanced Cancer Recruiting USA | GBR | AUS 1


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