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Therapy Name VIR-5818
Synonyms
Therapy Description

VIR-5818 is a prodrug T-cell engager that targets CD3 and ERBB2 (HER2) which is activated in the tumor microenvironment, potentially resulting in activation of an immune response against ERBB2 (HER2)-expressing tumors and inhibition of tumor growth (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P193).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
VIR-5818 AMX 818|AMX818|VIR5818|VIR 5818|AMX-818 CD3 Antibody 119 HER2 (ERBB2) Antibody 79 VIR-5818 is a prodrug T-cell engager that targets CD3 and ERBB2 (HER2) which is activated in the tumor microenvironment, potentially resulting in activation of an immune response against ERBB2 (HER2)-expressing tumors and inhibition of tumor growth (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P193).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05356741 Phase Ib/II Pembrolizumab + VIR-5818 VIR-5818 To Access the Safety and Effects of Intravenous Administration of VIR-5818 Alone and in Combination With Pembrolizumab in Adult Participants With Locally Advanced or Metastatic HER2-Expressing Cancers Recruiting FRA | ESP | AUS 1


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