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Therapy Name TAK-280
Synonyms
Therapy Description

TAK-280 is a conditional bispecific redirected activation T-cell engager targeting CD276 (B7-H3) and CD3, which is activated in the tumor microenvironment and redirects cytotoxic T-lymphocytes towards tumor cells expressing CD276 (B7-H3), potentially resulting in increased tumor cell killing (J Clin Oncol 2025 43: 16_suppl, TPS2684, NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TAK-280 TAK 280|TAK280|MVC280|MVC-280|MVC 280 CD276 Antibody 21 CD3 Antibody 119 TAK-280 is a conditional bispecific redirected activation T-cell engager targeting CD276 (B7-H3) and CD3, which is activated in the tumor microenvironment and redirects cytotoxic T-lymphocytes towards tumor cells expressing CD276 (B7-H3), potentially resulting in increased tumor cell killing (J Clin Oncol 2025 43: 16_suppl, TPS2684, NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05220098 Phase Ib/II TAK-280 First-in-Human Study of TAK-280 in Participants With Unresectable Locally Advanced or Metastatic Cancer Terminated USA | ESP | CAN | AUS 0


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