Therapy Detail
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| Therapy Name | RYZ101 |
| Synonyms | |
| Therapy Description |
RYZ101 is a radioconjugate comprising a somatostatin analog linked to Actinium-225, which delivers radiation to tumor cells expressing SSTRs with a high affinity for SSTR2, potentially inhibiting tumor growth (PMID: 37616528). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| RYZ101 | RYZ-101|RYZ 101|225Ac-DOTATATE RYZ101 | RYZ101 is a radioconjugate comprising a somatostatin analog linked to Actinium-225, which delivers radiation to tumor cells expressing SSTRs with a high affinity for SSTR2, potentially inhibiting tumor growth (PMID: 37616528). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05477576 | Phase III | Everolimus Lanreotide acetate RYZ101 Sunitinib Octreotide acetate | Study of RYZ101 Compared With SOC in Pts w Inoperable SSTR+ Well-differentiated GEP-NET That Has Progressed Following 177Lu-SSA Therapy (ACTION-1) | Recruiting | USA | NLD | FRA | ESP | CAN | BRA | BEL | 1 |
| NCT06411301 | Phase I | RYZ101 | A Phase I Study to Assess the Tolerability of 225Ac-DOTATATE in Patients With Refractory and Relapsing Multiple Myeloma Expressing Somatostatin Receptors (AcTRESS) | Withdrawn | BEL | 0 |
| NCT07150806 | Phase Ib/II | RYZ101 | RYZ101 for the Treatment of Progressive or Recurrent Intracranial Meningioma | Suspended | USA | 0 |
| NCT06590857 | Phase Ib/II | Pembrolizumab + RYZ101 RYZ101 | Trial of 225Ac-DOTATATE (RYZ101) Alone and with Pembrolizumab in Subjects with ER+, HER2-negative Unresectable or Metastatic Breast Cancer Expressing SSTRs (TRACY-1) | Active, not recruiting | USA | CAN | 1 |
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