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Therapy Detail
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| Therapy Name | Bortezomib + Pomalidomide + TAK-573 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bortezomib | Velcade | Velcade (bortezomib) is a reversible proteasome inhibitor that inhibits survival of malignant cells and regulates bone remodeling (PMID: 26579531). Velcade (bortezomib) is FDA approved for the treatment of mantle cell lymphoma and multiple myeloma (FDA.gov). | ||
| Pomalidomide | Pomalyst | CC-4047 | Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov). | |
| TAK-573 | TAK 573|TEV-48573|TAK573|TEV48573|TEV-48573|Modakafusp Alfa | CD38 Antibody 21 | TAK-573 is a fusion of an anti-CD38 antibody and attenuated IFN-alpha, which potentially inhibits tumor growth (Clinical Lymphoma, Myeloma and Leukemia, Volume 19, Issue 10, e116). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05556616 | Phase I | Lenalidomide + TAK-573 Pomalidomide + TAK-573 Bortezomib + TAK-573 Carfilzomib + TAK-573 Bortezomib + Pomalidomide + TAK-573 Carfilzomib + Pomalidomide + TAK-573 Carfilzomib + Daratumumab + TAK-573 Daratumumab + Pomalidomide + TAK-573 | A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma | Completed | USA | ISR | ESP | BEL | 0 |
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