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Therapy Detail

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Therapy Name Bortezomib + Pomalidomide + TAK-573
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Bortezomib Velcade Velcade (bortezomib) is a reversible proteasome inhibitor that inhibits survival of malignant cells and regulates bone remodeling (PMID: 26579531). Velcade (bortezomib) is FDA approved for the treatment of mantle cell lymphoma and multiple myeloma (FDA.gov).
Pomalidomide Pomalyst CC-4047 Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov).
TAK-573 TAK 573|TEV-48573|TAK573|TEV48573|TEV-48573|Modakafusp Alfa CD38 Antibody 21 TAK-573 is a fusion of an anti-CD38 antibody and attenuated IFN-alpha, which potentially inhibits tumor growth (Clinical Lymphoma, Myeloma and Leukemia, Volume 19, Issue 10, e116).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05556616 Phase I Lenalidomide + TAK-573 Pomalidomide + TAK-573 Bortezomib + TAK-573 Carfilzomib + TAK-573 Bortezomib + Pomalidomide + TAK-573 Carfilzomib + Pomalidomide + TAK-573 Carfilzomib + Daratumumab + TAK-573 Daratumumab + Pomalidomide + TAK-573 A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma Completed USA | ISR | ESP | BEL 0


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