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Therapy Name Carfilzomib + Pomalidomide + TAK-573
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Carfilzomib Kyprolis PR-171 Kyprolis (carfilzomib) binds to the 20S proteasome and inhibits its protein degradation activity, thereby leading to the accumulation of ubiquinated proteins, which may result in apoptosis and growth arrest in tumor cells (PMID: 26893241). Kyprolis (carfilzomib) in combination with lenalidomide and dexamethasone, or in combination with Darzalex Faspro (Daratumumab and hyaluronidase-fihj) and dexamethasone is FDA-approved for use in patients with multiple myeloma (FDA.gov).
Pomalidomide Pomalyst CC-4047 Pomalyst (pomalidomide) is a thalidomide derivative that inhibits angiogenesis and modulates immune response, potentially lead to antitumor activity (PMID: 30069630). Pomalyst (pomalidomide) is FDA approved for use in patients with Kaposi's sarcoma who failed HAART or are HIV-negative, and in combination with dexamethasone in patients with multiple myeloma who had 2 or more prior therapies (FDA.gov).
TAK-573 TAK 573|TEV-48573|TAK573|TEV48573|TEV-48573|Modakafusp Alfa CD38 Antibody 20 TAK-573 is a fusion of an anti-CD38 antibody and attenuated IFN-alpha, which potentially inhibits tumor growth (Clinical Lymphoma, Myeloma and Leukemia, Volume 19, Issue 10, e116).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05556616 Phase I Lenalidomide + TAK-573 Pomalidomide + TAK-573 Bortezomib + TAK-573 Carfilzomib + TAK-573 Bortezomib + Pomalidomide + TAK-573 Carfilzomib + Pomalidomide + TAK-573 Carfilzomib + Daratumumab + TAK-573 Daratumumab + Pomalidomide + TAK-573 A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma Completed USA | ISR | ESP | BEL 0


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