Therapy Detail
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| Therapy Name | Enzalutamide + Zenocutuzumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Enzalutamide | Xtandi | MDV3100|ASP9785 | Hormone - Anti-androgens 58 | Xtandi (enzalutamide) is a second-generation small molecule inhibitor of androgen receptor, thereby resulting in decreased tumor growth (PMID: 24009414, PMID: 25945058). Xtandi (enzalutamide) is FDA-approved for use in patients with castration-resistant prostate cancer, metastatic hormone-sensitive prostate cancer, and non-metastatic castration-sensitive prostate cancer with biochemical recurrence at high risk for metastasis (FDA.gov). |
| Zenocutuzumab | Bizengri | MCLA-128|MCLA128|MCLA 128|zenocutuzumab-zbco | HER2 (ERBB2) Antibody 80 HER3 (ERBB3) Antibody 29 | Bizengri (zenocutuzumab) is a bispecific antibody that targets Erbb2 (Her2) and Erbb3, resulting in antibody-dependent cell-mediated cytotoxicity against tumor cells (Cancer Res 2016;76(14 Suppl):Abstract nr CT050, PMID: 32054397). Bizengri (zenocutuzumab) is FDA-approved for use in patients with advanced, unresectable, or metastatic non-small cell lung cancer harboring NRG1 fusions, in patients with advanced, unresectable, or metastatic pancreatic adenocarcinoma harboring NRG1 fusions, and in patients with advanced, unresectable, or metastatic pancreatic cholangiocarcinoma harboring NRG1 fusions (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05588609 | Phase II | Enzalutamide + Zenocutuzumab Afatinib + Zenocutuzumab Abiraterone + Zenocutuzumab | Study Evaluating Zenocutuzumab in Patients With or Without Molecularly Defined Cancers | Terminated | USA | 0 |
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